Genetic and Environmental Predisposing Factors of Autism Spectrum Disorders
نویسندگان
چکیده
منابع مشابه
Maternal lifestyle and environmental risk factors for autism spectrum disorders.
BACKGROUND Over the past 10 years, research into environmental risk factors for autism has grown dramatically, bringing evidence that an array of non-genetic factors acting during the prenatal period may influence neurodevelopment. METHODS This paper reviews the evidence on modifiable preconception and/or prenatal factors that have been associated, in some studies, with autism spectrum disord...
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Although autism is considered to be one of the most highly heritable psychiatric disorders, molecular mechanisms underlying its pathogenesis remain largely unresolved. A strong genetic component underlying autism spectrum disorders (ASD) has been firmly established from various lines of studies ranging from whole genome scans to genetic association studies. Recent genomic advances have led to s...
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The autism spectrum disorders (ASD) are characterized by impairments in social interaction and stereotyped behaviors. For the majority of individuals with ASD, the causes of the disorder remain unknown; however, in up to 25% of cases, a genetic cause can be identified. Chromosomal rearrangements as well as rare and de novo copy-number variants are present in ∼10-20% of individuals with ASD, com...
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Understanding the pathogenesis of neurodevelopmental disorders has proven to be challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental disorder, this article reviews the existing literature on the etiological substrates of ASD and explores how genetic epidemiology approaches including gene-environment interactions (G×E) can play a role in identifying factors asso...
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ژورنال
عنوان ژورنال: Journal of Experimental and Basic Medical Sciences
سال: 2020
ISSN: 2717-9478
DOI: 10.5606/jebms.2020.75604